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KMID : 0363220150530040270
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Korean Journal of Dermatology
2015 Volume.53 No. 4 p.270 ~ p.276
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A Study on the Number of Circulating CD4+CD25+Foxp3+ Regulatory T Cells and CD4+CD25?Foxp3+ T Cells in Psoriasis
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Song Sang-Hyun
Kim Dong-Jin
Na Chan-Ho
Kim Min-Sung
Shin Bong-Seok
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Abstract
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Background: Regulatory T cells (Treg) are able to inhibit the immunological response and maintain cutaneous immunological homeostasis, thus preventing autoimmunity against itself. In several studies, the importance of CD4+CD25+Foxp3+ Treg in psoriasis has been examined, using the peripheral blood of patients. However, limited studies on Treg are available and shows conflicting results. Recently, CD4+CD25.Foxp3+ T cells were identified as being the peripheral reservoir of CD4+CD25+Foxp3+ Treg.
Objective: The purpose of this study was to investigate differences in the CD4+CD25+Foxp3+ Treg and CD4+CD25. Foxp3+ T cell counts between patients with psoriasis and normal controls.
Methods: For phenotypic analysis, the proportions and absolute cell numbers of CD4+CD25+Foxp3+ Treg and CD4+CD25.Foxp3+ T cells in the peripheral blood were examined by flow cytometry. The correlation between the CD4+CD25+Foxp3+ Treg count and other parameters (age of onset, disease duration, BSA, psoriasis area and severity index score, and clinical stage) was also analyzed.
Results: Although the CD4+CD25+Foxp3+ Treg count was slightly increased while the number of CD4+CD25. Foxp3+ T cells was slightly decreased in psoriasis patients than that of the controls, the differences between the groups were not statistically significant (5.27±2.60 vs. 4.70±1.35, p＞0.05; 1.56±1.07 vs. 1.93±1.08, p＞0.05). The CD4+CD25+Foxp3+ Treg count did not correlate with the tested parameters except for the clinical stage of psoriasis. The mean±SD number of CD4+CD25+Foxp3+ Treg in the stable phase was higher than that in the progressive phase (7.26±2.58 vs. 4.35±2.10, p＜0.05). The CD4+CD25.Foxp3+ T cell count did not show any significant correlation with all the parameters tested (p＞0.05).
Conclusion: These findings suggest that the CD4+CD25+Foxp3+ Treg count alone is insufficient to explain the pathogenesis and severity of psoriasis. However, a decrease in circulating CD4+CD25+Foxp3+ Treg is likely to be correlated with an aggravation of psoriasis.
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KEYWORD
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CD4+CD25+Foxp3+ regulatory T cell , CD4+CD25.Foxp3+ T cell , Psoriasis
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